Aprotinin therapy
نویسندگان
چکیده
منابع مشابه
Reduced inotropic support after aprotinin therapy during pediatric cardiac operations.
BACKGROUND Several reports indicate that aprotinin treatment before and during cardiopulmonary bypass (CPB) might have a protective effect on the myocardium. We evaluated the hemodynamic effects of perioperative aprotinin treatment. METHODS We conducted a randomized, double-blind, placebo-controlled trial in 34 infants (mean age, 2.5 years) who had cardiac operations. Half of the patients rec...
متن کاملMonitoring Anticoagulation During Aprotinin Utilization
The literature reviewed discussed the varying practices of anticoagulation measurement in those open heart patients receiving aprotinin. All references have reported an increase in celite ACTs (C-ACTs) in heparinized patients who were treated with aprotinin. Two authors attributed this effect to aprotinin's ability to enhance heparin's anticoagulation and therefore permit a decrease in the hepa...
متن کامل99mTc-aprotinin scintigraphy in amyloidosis.
UNLABELLED Changes in the amount and distribution of amyloid lesions have been difficult to monitor because they can usually be demonstrated only by evident symptoms or from a biopsy. The recent progress in the treatment of amyloidosis stresses the need for an early diagnosis and the need for noninvasive monitoring during the course of treatment. To validate (99m)Tc-aprotinin scintigraphy, we s...
متن کاملAprotinin in orthotopic liver transplantation.
Aprotinin is a protease inhibitor isolated from bovine lungs and othcr lissues. Its biochcmical struc!Urc, a single-chain polypeptide of 6.5 12 kD , and biophysical properties are weH defined. I The activity of commcrcial preparations of apralini n is usually describcd in kallikrein inac ti valor unils (KIU) , 0. 1 million KIU being equivalent 102. 15 j-Lmol of apralinin per liter. Sy inhibitin...
متن کاملEconomic evaluation of high-dose and low-dose aprotinin therapy during cardiopulmonary bypass.
BACKGROUND Aprotinin therapy is now widely used during cardiac surgery. This study examined the clinical and economic effectiveness of high-dose or low-dose aprotinin in comparison to placebo. METHODS In a double blind, randomized study, three groups of 50 patients received high-dose aprotinin costing AUS$614 per patient (AUS$ = Australian dollars), low-dose aprotinin costing AUS$220 per pati...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1995
ISSN: 0007-0912
DOI: 10.1093/bja/75.2.246